
Single-Pot System
In the DIOSNA VAC Single-Pot processors, your wet granules are produced and then dried under vacuum.
Cool vacuum developed a complete range of industrial freeze dryers, with a useful shelf area from 0.5 to 45 m2, to cover different production needs. With 5 basic models and more than 40 optional features, Cool vacuum freeze dryers can be adapted
to the specific needs of our clients. Using only the best and most reliable materials and components, our equipment complies with the quality levels expected by the advanced pharmaceutical industry.
| Quality and performance standards | |
| Performance data | |
| Sublimation rate | from 1 to 35 kg/h |
| Preparation time between batches (CIP / SIP, drying, cooling) | 8 h |
| Chamber | |
| Surface roughness | 0.8 µm |
| System leak rate | 0.008 mbar x l/s |
| Shelves | |
| Flatness on shelf surface | 1 mm/m |
| Surface roughness on top side (Ra) | 0.8 µm |
| Surface roughness on bottom side (Ra) | 0.8 – 1.4 µm |
| Temperature distribution on one shelf | <1 °C |
| Temperature distribution in shelves stack | <1.5 °C |
| Temperature difference between the inlet and outlet of a shelf | <1 °C |
| Condenser | |
| Inner surface of condenser | Mirror |
| Surface roughness of condenser coil | Cold drawn |
| Defrosting time | from 20 to 60 min |
| Evaporation surface ratio vs shelf surface | 0.99 m2/m2 |
| Cooling and heating | |
| Shelves cooling rate from +20 ºC to -40 ºC | 1.5 °C/min |
| Shelves heating rate from -40 ºC a +60 ºC | 1.5 °C/min |
| Temperature range during drying | from -50 °C to +60 °C |
| Condenser cooling rate +20 to -40ºC | 1.5 °C/min |
| Final condenser temperature | -75 °C |
| Vaccuum | |
| Final system vacuum | 0.005 mbar |
| Final vacuum of freeze dryer | 0.01 mbar |
| Vacuum evacuation time from 1,000 a 0.1 mbar | 30 min |

In the DIOSNA VAC Single-Pot processors, your wet granules are produced and then dried under vacuum.

Filling from 0.1 ÷ 100 ml / Output up to 22,600 uph

Multiformat machines / Quick format changeover / Output up to 36,000 uph

The P1-6 laboratory mixer combines the highest quality mixing, granulation and pelletizing in one machine.